SERVICES

Antibody Humanization and Optimization Service

Detailed sequence
analysis and 3D
structure modeling

Identification of the
best human germline
sequence templates
and grafting the rodent
or rabbit antibody
CDR regions into the
human antibody
frameworks

Identifying back-
mutations and
removing “hot spots”
with developability
issues

High-throughput lead
selection and evaluation

Service

Efficient lead preparation
for research purposes
in-house (up to 20mg)
and CMC level protein
preparation at partner
facilities

Antibody humanization and optimization workflow

Pick from our several available options

$30,000

  • 1 + 2
  • UPFRONT: $20,000
  • DESIGN FEE: $10,000
Golden Design

$60,000

  • 1 + 2 + 3
  • UPFRONT PAYMENT: $20,000
  • PRELIMINARY SCREENING: $30,000
  • DESIGN FEE: $10,000
Golden Design +
Preliminary Screening

$90,000

  • 1 + 2 + 3 + 4
  • UPFRONT PAYMENT: $20,000
  • PRELIMINARY SCREENING: $ 30,000
  • DESIGN FEE: $10,000
  • SECONDARY ROUND SCREENING: $20,000
  • LEAD IGG PRODUCTION AND
  • CHARACTERIZATION: $10,000
Diamond Full
Humanization Service

The Humanization and optimization design starts after receiving a $20,000 upfront payment. Client will receive a design report without sequence information for approval within 2 weeks. Preliminary screening will start after the client approval of the design and the upfront payment. Clients may choose to receive the preliminary screening data without the second round of sequence optimization for affinity (6 weeks) or including that (10 weeks). After client approval, a $35,000 fee will be charged for protein production, purification, and second round screening (8 weeks without further sequence optimization for developabolty, 12weeks including that. The client will then receive the data for selecting the final lead sequence. Upon receiing the lead production and remaining design fees from the client Ab Studio will purify 10 mg of the final lead antibody and send it to the client together with any remaining antibodies from the first round of screening and the full antibody humanization/optimization report containing all designed sequences.

Significant discounts will be provided for start-ups and/or multiple projects! Contact us for more details.

3541 Investment Blvd. Suite 3,
Hayward, CA 94545 USA