Use CAAD to identify epitopes exposed on antigens. Immunize mice based on target biology, 3D information and bioinformatics. Then, HT binding, functional, and epitope binning assays are performed to screen the best antibodies. Apply CAAD to select candidates with good developability features.
Human naïve ScFv, Llama naïve, and Llama humanized VHH libraries are used to discover hits. CAAD is used to select candidates with good developability features such as less aggregation, less PTMs, and low immunogenicity.
Candidates with best safety, efficacy, and developability balance are selected as leads.
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