Monoclonal Antibody Discovery

Antibody discovery by hybridoma technology

Use CAAD to identify epitopes exposed on antigens. Immunize mice based on target biology, 3D information and bioinformatics. Then, HT binding, functional, and epitope binning assays are performed to screen the best antibodies. Apply CAAD to select candidates with good developability features.

Antibody screening with phage display technology

Human naïve ScFv, Llama naïve, and Llama humanized VHH libraries are used to discover hits. CAAD is used to select candidates with good developability features such as less aggregation, less PTMs, and low immunogenicity.

Antibody discovery by hybridoma and phage display technologies, combined with computer aided antibody design (CAAD)

Lead selection

Candidates with best safety, efficacy, and developability balance are selected as leads.

3541 Investment Blvd. Suite 3,
Hayward, CA 94545 USA