Antibody discovery by hybridoma and phage display technologies, combined with computer-aided antibody design (CAAD).
Antibody discovery by hybridoma
technology.
Use CAAD to identify epitopes
exposed on antigens. Design and
implement immunization strategies
based on target biology, 3D
information and bioinformatics.
HT binding, functional, and epitope
binning assays to screen the best
antibodies. Apply CAAD to select
candidates with good developability
features.
Antibody screening with phage
display technology.
Human naïve ScFv, Llama naïve,
and Llama humanized VHH
libraries are used to discover hits.
CAAD is used to select candidates
with good developability features
such as less aggregation, less
PTMs, and low immunogenicity.
Lead selection.
Candidates with best safety, efficacy,
and developability balance are
selected as leads.
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Hayward, CA 94545 USA
