Technology

Immunogenecity

Affinity

Humanization

Computer Aided Antibody Design (Caad)

Traditional Technologies Hybridoma

Traditional Technologies Phage Display

Stability

Expression

Developability

Imbalanced Bispecific Antibodies
Bispecific antibodies with computationally optimized differential binding affinities, biochemical and biophysical features, and a common light chain.

T cell engager bispecific antibodies

Bispecifics against a CSA & CAA

Bispecifics against a CNS target and a BBB (blood brain barrier) target

Development of a novel "imbalanced" CSA bispecific antibody by computational design

Biospecific involves a CD3 binder

Development of Multi-Specific Antibodies by computational design

Start from unknown target antigen

Start from known target antigen

Unique feature of second strategy: Screening internalization caused by primary Ab.

Ab Studio's Internalizing Antibody Case Study: Antibody Against Cancer Antigen-X

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