Therapeutic Antibody Discovery Partnership
1
Monoclonal Antibody discovery service: hybridoma and phage display
Antigen design via bioinformatics and computer aided design
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Antibody development via hybridoma and/or phage display technology
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Screening mAb clones for high affinity, high expression, good efficacy and good developability
2
Bispecific antibody discovery partnership
Apply “knob into hole” plus common light chain technology for bispecific antibody development
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Use Ab Studio’s unique methodology to screen common light chain
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Apply computer aided design to engineer the two arms of a bi-specifc antibody for better purification efficacy
3
Internalization antibody discovery partnership
Apply Ab Studio’s unique methodology to screen hybridoma clones secreting cancer specifc internalization antibodies or phages display internalization antibodies
Workflow And Timeline For Antibody Discovery With Hybridoma Technology
Membrane Protein Immunization
Our DNA immunization is applying
IP free protocol
Soluble Protein Immunization
Phage Display
Antigen specific ScFV phage library construction with immunized mouse B cells (if needed), 3-4 months, $30,000
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Panning with Ab Studio’s in house human naïve ScFV phage library or the new constructed antigen specific library, 1 month, $30,000 for 10 binding leads
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Analyze VH:VL interface naturality and developability of ScFV sequence, 1 month, $30,000
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Lead IgG production and characterization with assay developed by clients, 1 month, price TBD